Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts

A guinea-pig model of cardiac injury is used to show that human embryonic stem-cell-derived cardiomyocyte grafts can electrically integrate into the injured heart, improving mechanical function and reducing spontaneous and induced ventricular tachycardia; this is a major step towards clinical adoption of cell replacement therapies for cardiovascular diseases using human cardiomyocytes.

doi: http://dx.doi.org/10.1038/nature11317

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Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts

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