A capacitive deionization process utilizing flow-electrodes (FCDI) was designed and evaluated for use in seawater desalination. The FCDI cell exhibited excellent removal efficiency (95%) with respect to an aqueous NaCl solution (salt concentration: 32.1 g L−1), demonstrating that the FCDI process could effectively overcome the limitations of typical CDI processes. DOI: http://dx.doi.org/10.1039/C3EE24443A